Endocrine Abstracts

Objective: Despite beneficial effect of FGF-21 on metabolic disease, there were concerns about adverse effect on bone metabolism, supported by animal studies. However, a recent human study showed the positive association between FGF-21 and bone mineral density (BMD) in health premenopausal women. This study was undertaken to examine the association between FGF-21 and BMD in healthy postmenopausal Korean women who are susceptible to osteoporosis.<p class="a...

Objective: Dipeptidyl peptidase (DPP)-4 is highly abundant in the kidney. In various chronic inflammatory diseases, soluble DPP-4 activity is used as a marker for diabetes, coronary artery disease and cancer. This study examined the association between serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus.Research design and methods: Soluble DPP-4 activities were measured retrospectively in a total...

Background/objectives: This study aimed to investigate associations between self-reported sleep duration and general and abdominal obesity in Korean adults stratified according to sex and age.Subjects/methods: Data from 41,805 adults, 18–110 years of age, collected by the Korean National Health and Nutrition Examination Survey (KNHANES) in 2007 and 2015, were included. Obesity was defined as body mass index (BMI) ≥25 kg/m2, and abdo...

Adiponectin has been thought to exert important influences in energy homeostasis and insulin signalling pathway. Some obese individuals showed paradoxical hyperadiponectine-mia (HA), however, the effect of HA on bone metabolism has not been fully clarified.This study aimed to evaluate bone strength and metabolic parameters according to the presence of HA and obesity in Korean adults. A total of 9,172 adults (59.4% women) aged 40–70 years assessed in...